Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies

Picetti, Roberto; Shakur-Still, Haleema; Medcalf, Robert L.; Standing, Joseph F.; Roberts, Ian

(2019), BLOOD COAGUL FIBRIN, 30(1), 1-10.

DOI: 10.1097/MBC.0000000000000789

A review of global coagulation assays — Is there a role in thrombosis risk prediction?

Lim, Hui Yin; O'Malley, Cindy; Donnan, Geoffrey; Nandurkar, Harshal; Ho, Prahlad

(2019), THROMB RES, (179), 45-55.

DOI: 10.1016/j.thromres.2019.04.033

Genetic Variants Within the Erythroid Transcription Factor, KLF1, and Reduction of the Expression of Lutheran and Other Blood Group Antigens

Fraser, Nicole S.; Knauth, Christine M.; Moussa, Assia; Dean, Melinda M.; Hyland, Catherine A.; Perkins, Andrew C.; Flower, Robert L.; Schoeman, Elizna M.

(2019), TRANSFUS MED REV, 33(2), 111-117.

DOI: 10.1016/j.tmrv.2019.01.004

A comparison of the efficacy of immunomodulatory-free regimens in relapsed or refractory multiple myeloma

Weisel, Katja; Sonneveld, Pieter; Spencer, Andrew; Beksac, Meral; Rizzo, Maria; Xu, Yingxin; Fahrbach, Kyle; Gaudig, Maren; Slavcev, Mary; Dearden, Lindsay; Lam, Annette

(2019), LEUKEMIA LYMPHOMA, 60(19), 151–162.

DOI: 10.1080/10428194.2018.1466392

The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1

Shields, Benjamin J.; Slape, Christopher I.; Vo, Ngoc; Jackson, Jacob T.; Pliego-Zamora, Adriana; Ranasinghe, Hansini; Shi, Wei; Curtis, David J.; McCormack, Matthew P.

(2019), LEUKEMIA, 33(8), 1868-1880

DOI: 10.1038/s41375-018-0361-0

Renal impairment at diagnosis in myeloma: Patient Characteristics, Treatment, and Impact on Outcomes. Results From the Australia and New Zealand Myeloma and Related Diseases Registry

Ho, P. Joy; Moore, Elizabeth M.; McQuilten, Zoe K.; Wellard, Cameron; Bergin, Krystal; Augustson, Bradley; Blacklock, Hilary; Harrison, Simon J.; Horvath, Noemi; King, Tracy; Mollee, Peter; Quach, Hang; Reid, Christopher; Rosengarten, Brian; Walker, Patricia; Wood, Erica M.; Spencer, Andrew

(2019), CL LYMPH MYELOM LEUK, 19(8), E415-E424.

DOI: 10.1016/j.clml.2019.05.010

Oral azacitidine (CC-486) in combination with lenalidomide and dexamethasone in advanced, lenalidomide-refractory multiple myeloma (ROAR study)

Kalff, Anna; Khong, Tiffany; Mithraprabhu, Sridurga; Bergin, Krystal; Reynolds, John; Bowen, Kathryn M.; Thakurta, Anjan; Guzman, Roberto; Wang, Maria; Couto, Suzana; Ren, Yan; Spencer, Andrew

(2019), LEUKEMIA LYMPHOMA, 60(9), 2143-2151.

DOI: 10.1080/10428194.2019.1571201

Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications

Moore, Hunter B.; Moore, Ernest E.; Neal, Matthew D.; Sheppard, Forest R.; Kornblith, Lucy Z.; Draxler, Dominik F.; Walsh, Mark; Medcalf, Robert L.; Cohen, Mitch J.; Cotton, Bryan A.; Thomas, Scott G.; Leeper, Christine M.; Gaines, Barbara A.; Sauaia, Angela

(2019), ANESTH ANALG, 129(3), 762-773.

DOI: 10.1213/ANE.0000000000004234

Global coagulation assays in patients with multiple myeloma and monoclonal gammopathy of unknown significance

Lim, Hui Yin; Brook, Rowena; Krishnamoorthi, Brintha; Tacey, Mark; Leung, Teresa; Donnan, Geoffrey; Nandurkar, Harshal; Ho, Prahlad

(2019), THROMB RES, (183), 45-48.

DOI: 10.1016/j.thromres.2019.10.017

SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation

Schroder, Wayne A.; Le, Thuy T.; Gardner, Joy; Andrews, Robert K.; Gardiner, Elizabeth E.; Callaway, Leonie; Suhrbier, Andreas

(2019), PLATELETS, 30(5), 658-663.

DOI: 10.1080/09537104.2018.1535702

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

McRae, Helen M.; Garnham, Alexandra L.; Hu, Yifang; Witkowski, Matthew T.; Corbett, Mark A.; Dixon, Mathew P.; May, Rose E.; Sheikh, Bilal N.; Chiang, William; Kueh, Andrew J.; Nguyen, Tan A.; Man, Kevin; Gloury, Renee; Aubrey, Brandon J.; Policheni, Antonia; Di Rago, Ladina; Alexander, Warren S.; Gray, Daniel H.D.; Strasser, Andreas; Hawkins, Edwin D.; Wilcox, Stephen; Gécz, Jozef; Kallies, Axel; McCormack, Matthew P.; Smyth, Gordon K.; Voss, Anne K.; Thomas, Tim

(2019), BLOOD, 133(16), 1729-1741.

DOI: 10.1182/blood-2018-07-860726

A comparison of global coagulation assays between normal controls and patients with thrombocytopenia

Lim, Hui Yin; Leung, Patrick; Manitta, Vanessa; Nandurkar, Harshal; Ho, Prahlad

(2019), INT J LAB HEMATOL, 41(2), 184-191.

DOI: 10.1111/ijlh.12941

Platelet protein disulfide isomerase promotes glycoprotein ib&-mediated platelet-neutrophil interactions under thromboinflammatory conditions

Li, Jing; Kim, Kyungho; Jeong, Si Yeon; Chiu, Joyce; Xiong, Bei; Petukhov, Pavel A.; Dai, Xiangrong; Li, Xiaoyi; Andrews, Robert K.; Du, Xiaoping; Hogg, Philip J.; Cho, Jaehyung

(2019), CIRCULATION, 139(10), 1300-1319.

DOI: 10.1161/CIRCULATIONAHA.118.036323

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Ku, Matthew; MacKinnon, Ruth N.; Wall, Meaghan; Narayan, Nisha; Walkley, Carl; Cheng, Heung Chin; Campbell, Lynda J.; Purton, Louise E.; Nandurkar, Harshal

(2019), SCI REP-UK, 9(1), 7050

DOI: 10.1038/s41598-019-43373-6

Phase 2 study of all-oral ixazomib, cyclophosphamide and low-dose dexamethasone for relapsed/refractory multiple myeloma

Kumar, Shaji K.; Grzasko, Norbert; Delimpasi, Sosana; Jedrzejczak, Wieslaw W.; Grosicki, Sebastian; Kyrtsonis, Marie Christine; Spencer, Andrew; Gupta, Neeraj; Teng, Zhaoyang; Byrne, Catriona; Labotka, Richard; Dimopoulos, Meletios A.

(2019), BRIT J HAEMATOL, 184(4), 536-546.

DOI: 10.1111/bjh.15679

Tranexamic acid modulates the immune response and reduces postsurgical infection rates

Draxler, Dominik F.; Yep, Kah; Hanafi, Gryselda; Winton, Anoushka; Daglas, Maria; Ho, Heidi; Sashindranath, Maithili; Wutzlhofer, Lisa M.; Forbes, Andrew; Goncalves, Isaac; Tran, Huyen A.; Wallace, Sophia; Plebanski, Magdalena; Myles, Paul S.; Medcalf, Robert L.

(2019), Blood Adv, 3(10), 1598-1609.

DOI: 10.1182/bloodadvances.2019000092

Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis

Draxler, Dominik F.; Daglas, Maria; Fernando, Anushka; Hanafi, Gryselda; McCutcheon, Fiona; Ho, Heidi; Galle, Adam; Gregory, Julia; Larsson, Pia; Keragala, Charithani; Wright, David K.; Tavancheh, Elnaz; Au, Amanda E.; Niego, Be'eri; Wilson, Kirsty; Plebanski, Magdalena; Sashindranath, Maithili; Medcalf, Robert L.

(2019), J THROMB HAEMOST, 17(12), 2174-2187.

DOI: 10.1111/jth.14603

Shared roles for Scl and Lyl1 in murine platelet production and function

Chiu, Sung K.; Orive, Stephanie L.; Moon, Mitchell J.; Saw, Jesslyn; Ellis, Sarah; Kile, Benjamin T.; Huang, Yizhou; Chacon, Diego; Pimanda, John E.; Beck, Dominik; Hamilton, Justin R.; Tremblay, Cedric S.; Curtis, David J.

(2019), BLOOD, 134(10), 826-835.

DOI: 10.1182/blood.2019896175

Antiphospholipid syndrome: a clinical review

Mezhov, Veronica; Segan, Julian D.; Tran, Huyen; Cicuttini, Flavia M.

(2019), MED J AUSTRALIA, 211(4), 184-188.

DOI: 10.5694/mja2.50262

T-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke

Draxler, Dominik F.; Lee, Felix; Ho, Heidi; Keragala, Charithani B.; Medcalf, Robert L.; Niego, Be'eri

(2019), FRONT IMMUNOL, 10, MAR

DOI: 10.3389/fimmu.2019.00591

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