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The main purpose of this study is to see how well PRAX-628 works in treating focal onset seizures (the type of seizure that starts when only one area of the brain starts firing uncontrolled electrical signals) and primary generalised tonic-clonic seizures (the type of seizure that occurs when uncontrolled electrical activity affects the entire brain from the start). Additional purposes of this study are to see how safe PRAX-628 is and how the body processes (pharmacokinetics, PK) it. In this study, all participants will receive PRAX-628 30 mg (3 x 10 mg capsules) once daily (QD) for 8 weeks.

A double blinded randomised controlled pilot study comparing the outcomes of dapagliflozin vs placebo in patients with comatose cardiac arrest, with respect to hypoxic brain and ischaemia reperfusion injury

Probe-to-bone (PTB) test is a bedside test used to assess for bone infection in patients with diabetic foot ulcers, where a blunt metal probe is used to test for presence of bone within the ulcer bed. This study aims to evaluate the safety and feasibility of treating patients with diabetic foot ulcers and positive PTB test with shorter courses of antibiotic therapy in a low-risk setting.

To determine the effectiveness of posterior wall isolation in patients presenting for redo atrial fibrillation (AF) ablation with enduring pulmonary vein isolation (PVI).

About the QuANTUM-Wild Study: QuANTUM-Wild is a clinical trial for people who are newly diagnosed with acute myeloid leukaemia (AML) that is FLT3-ITD–negative. The purpose of the clinical trial is to evaluate an oral study drug called quizartinib—to see if it may improve this type of AML and is safe. This study drug is currently not approved for this condition, which is why it’s being evaluated. Everyone in the clinical trial will also receive the standard chemotherapy for their type of AML. This clinical trial will not delay the start of chemotherapy. Your study doctor may recommend that you receive a stem cell transplant. If so, your study doctor will be able to provide you with more information about this procedure. Although it is not part of this clinical trial, you may be able to continue participating in the clinical trial after you receive a stem cell transplant.