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This study evaluates whether increased atrial pacing rate decreases AF recurrence and burden for patients with AF and sinus node dysfunction undergoing AF ablation.

Many people in Australia are living with multiple long-term health conditions such as heart and lung disease, diabetes, arthritis, stroke, depression, and cancer. Exercise-based rehabilitation may help people with chronic conditions improve their physical function, symptoms and quality of life and help them spend less time in the hospital. However, until now there have been few exercise options for people living with multiple long-term health conditions. We are now conducting a study to see if a personalised rehabilitation program (PERFORM trial), which includes exercises and education sessions, can improve wellbeing and physical function better than usual care in people with multiple long-term health conditions.

This is a multicentre single-arm prospective phase II trial evaluating pirtobrutinib in the treatment of relapsed/refractory (R/R) Chronic Lymphocytic Leukaemia (CLL) patients who have previously received zanubrutinib, and to specifically evaluate Bruton Tyrosine Kinase (BTK) mutational status (clonal dynamics) before, during and after treatment with pirtobrutinib.