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A prospective, multi-centre, single-arm non-randomised phase 2 clinical trial. This study will aim to deliver SABR to the prostate 35 Gy in 5 fractions, one fraction per week, in individuals with de novo metastatic prostate cancer.

This trial is direct entry only for anyone who completed the 3027 program

The Ntrust-2 study is looking for adults ages 18–70 to take part in research on an investigational cell therapy, called NKX019. NKX019 is being studied to see if it can safely target the root cause of systemic sclerosis (SSc or scleroderma), idiopathic inflammatory myopathy (IIM or myositis) or ANCA-associated vasculitis (AAV or polyangiitis). NKX019 is made from natural killer (NK) cells, which are white blood cells and a normal part of everyone’s immune system. For this study, NK cells are collected from healthy donors and specially processed into NKX019. NKX019 is made from white blood cells called natural killer (NK) cells. NK cells are the immune system’s first responders and possess a unique, natural ability to target and kill disease-causing cells. NK cells are a normal part of the immune system and are present in everyone. The NK cells used in NKX019 are collected from healthy donors and then processed for use in NK cell therapy.

The purpose of the study is to evaluate the safety of NVG-2089 and to evaluate how well patients respond to this investigational treatment. NVG-2089 is a new drug that is being developed for treating patients with CIDP. NVG-2089 is designed to mimic the effects of a protein called IVIg. NVG-2089 is designed to potentially help the immune system by attaching (binding) to certain receptors in the body and activating them, which helps reduce inflammation and supports how the immune system works.

The purpose of this study is to evaluate the clinical efficacy and safety of OD-07656 in participants with moderately to severely active ulcerative colitis (UC). In addition, the study will evaluate the potential of OD-07656 to enhance the therapeutic benefit of vedolizumab when given after OD-07656.

This study evaluates whether increased atrial pacing rate decreases AF recurrence and burden for patients with AF and sinus node dysfunction undergoing AF ablation.