Pilot randomised controlled trial of probe to bone diabetic foot ulcer therapy (ACTRN12624000266561)

Probe-to-bone (PTB) test is a bedside test used to assess for bone infection in patients with diabetic foot ulcers, where a blunt metal probe is used to test for presence of bone within the ulcer bed. This study aims to evaluate the safety and feasibility of treating patients with diabetic foot ulcers and positive PTB test with shorter courses of antibiotic therapy in a low-risk setting.

Trial phase

Phase 2

Trial participation type

This trial is for clinical research of something other than a drug or device.

Principal investigator

Dr Trisha Peel

Key inclusion data

Inclusion Criteria: Adult patient (?18 years) with probe-to-bone diabetic foot ulcers; X-ray performed within 72 hours of enrollment demonstrating no changes suggestive of osteomyelitis at the site of the ulcer. Exclusion criteria: Antibiotic therapy for >7 days in the 30 days prior to initial enrollment; Systemic signs of sepsis; Initial surgical therapy deemed more appropriate than medical management alone of diabetic foot infection.