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Our clinical trial portfolio is one of the largest in the country. We have more than 700 clinical trials open across 30 clinical units.

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599 clinical trials found

Clinical trials

LIBRETTO-531

A Multicenter, Randomized, Open-label, Phase 3 Trial Comparing LOXO-292 to Physicians Choice of Cabozantinib or Vandetanib in Patients with Progressive, Advanced, Kinase Inhibitor Naïve, RET-Mutant Medullary Thyroid Cancer (LIBRETTO-531) (NCT04211337)

Currently recruiting

Librexia Study

A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack (NCT05702034)

Currently recruiting

LIGHTRAY

A Phase 2, Multicenter, Single-blinded, Randomized Study to Evaluate the Pharmacokinetics and Safety of Sotatercept [MK-7962] Administered Using Either a Weight-based or Weight-banded Approach in Participants With Pulmonary Arterial Hypertension [PAH] on Standard of Care (NCT06664801)

Currently recruiting

LIGHTRAY EXT

An Open-label Extension Study to Evaluate Safety and Tolerability of Sotatercept [MK-7962] Administered Using a Weight-banded Approach in Participants With Pulmonary Arterial Hypertension [PAH] on Standard of Care (NCT06925750)

This is an extension study, which means people who took part in MK-7962-024 (LIGHTRAY) may be able to join this study. In this extension study, people will get weight-banded doses of?sotatercept. The main goal of this study is to learn about the safety of weight-banded doses of?sotatercept?and if people tolerate it over a longer period of time.

Currently recruiting

LIVER-R

An Observational Multi center Study to Evaluate Real World Treatment Outcomes of Durvalumab based Regimens in Hepatobiliary Cancers [LIVER-R] (NCT06252753)

Currently recruiting

LM108-01-101

A Phase I/II, First-in-Human (FIH), Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of LM-108 (an Anti-CCR8 mAb) as a Single Agent or in Combination with Anti-PD-1 Antibody in Subjects with Advanced Solid Tumours (NCT05199753)

Currently recruiting

LM302

A Phase I/II, Open-Label, Multiple Centre Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of LM302 in Combination with Toripalimab in Patients with Advanced Solid Tumors (NCT05188664)

No longer recruiting

LOLIPOP

Long-Term Outcomes of Lidocaine Infusions for Post-Operative Pain: the LOLIPOP Trial (NCT05072314)

Currently recruiting

LONGBOARD-DB

A Phase 1b/2a randomized, double-blind, placebo-controlled, parallel-group, dose-escalation study to investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of LP352 in subjects with developmental and epileptic encephalopathies. (NCT05364021)

Currently recruiting

LONGBOARD-OLE

A Phase 2, multicenter, open-label, long-term safety study of LP352 in subjects with developmental and epileptic encephalopathy who completed Study LP352-201 and are candidates for continuous treatment for up to 52 weeks (NCT05626634)

Currently recruiting

Longevity LBT3627-101

A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LBT-3627 in Healthy Subjects and in Subjects with Parkinson’s disease (NCT06466525)

Currently recruiting

Low Risk TAVI

Transcatheter Aortic Valve Replacement With the Medtronic Transcatheter Aortic Valve Replacement System In Patients at Low Risk for Surgical Aortic Valve Replacement (NCT02701283)

Currently recruiting

LOXO-BTK-20020

A Phase 3 Open-Label, Randomized Study of LOXO-305 versus Investigator’s Choice of Idelalisib plus Rituximab or Bendamustine plus Rituximab in BTK Inhibitor Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-321) (NCT04666038)

Currently recruiting

LOXO-BTK-20022

A Phase 3 Open-Label, Randomized Study of Fixed Duration Pirtobrutinib (LOXO-305) plus Venetoclax and Rituximab versus Venetoclax and Rituximab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-322) (NCT04965493)

Currently recruiting

LTS17367 RIVER-AD

A long-term extension study to evaluate the long-term safety, tolerability and efficacy of subcutaneous amlitelimab in participants of previous amlitelimab clinical trials in moderate to severe atopic dermatitis (NCT05492578)

This is a multinational, multicenter, randomized, double-blind, placebo-controlled, parallel, Phase 3 study for treatment of participants aged 12 years and older diagnosed with moderate-to-severe atopic dermatitis (AD). The main objective of this study is to evaluate if those participants who received amlitelimab dose 1 in the parent studies (EFC17559 [COAST-1], EFC17560 [COAST 2], EFC17561 [SHORE]) and were responders can maintain their response either remaining at dose 1 or switching to dose 2 of amlitelimab compared to treatment withdrawal.

Currently recruiting

LuMIERE

LuMIERE: A Phase 1/2 Multicenter, Open-label, Non-randomized Study to Investigate Safety and Tolerability, Pharmacokinetics, Dosimetry, and Preliminary Activity of [177Lu]Lu-FAP-2286 in Participants with an Advanced Solid Tumor (NCT04939610)

Currently recruiting

Lung Tx - Biomarker III

IDENTIFYING IMMUNE AND INFECTIOUS BIOMARKERS OF EARLY AND LATE ALLOGRAFT DYSFUNCTION FOLLOWING LUNG TRANSPLANTATION (Trial Not Registered)

No longer recruiting

LWH RCT

A Type II Hybrid Effectiveness-Implementation, Randomised Control Trial of Left Write Hook for Adult Survivors of Child Sexual Abuse (ACTRN12624000862549)

Currently recruiting

M20-350

A Multicenter, Single-Arm Prospective Study to Evaluate Safety and Efficacy of GLE/PIB 8-Week Treatment in Adults and Adolescents with Acute Hepatitis C Virus (HCV) Infection (NCT04903626)