Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Lee WT, Cain JE, Cuddihy A, Johnson J, Dickinson A, Yeung KY, Kumar B, Johns TG, Watkins DN, Spencer A, St John JC

(2016), Cell Death Discov, 2

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse

Larsson P, Alwis I, Niego B, Sashindranath M, Fogelstrand P, Wu MC, Glise L, Magnusson M, Daglas M, Bergh N, Jackson SP, Medcalf RL, Jern S

(2016), J Thromb Haemost, 14(12)

PTP1B deficiency enables the ability of a high-fat diet to drive the invasive character of PTEN-deficient prostate cancers

Labbé DP, Uetani N, Vinette V, Lessard L, Aubry I, Migon E, Sirois J, Haigh JJ, Bégin LR, Trotman LC, Paquet M, Tremblay ML

(2016), Cancer Res, 76(11)

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurn

(2016), Nature, 538(7626)

Ablation of type-1 IFN signaling in hematopoietic cells confers protection following traumatic brain injury

Karve IP, Zhang M, Habgood M, Frugier T, Brody KM, Sashindranath M, Ek CJ, Chappaz S, Kile BT, Wright D, Wang H, Johnston L, Daglas M, Ates RC, Medcalf RL, Taylor JM, Crack PJ

(2016), eNeuro, 3(1)

GAPTrap: a simple expression system for pluripotent stem cells and their derivatives

Kao T, Labonne T, Niclis JC, Chaurasia R, Lokmic Z, Qian E, Bruveris FF, Howden SE, Motazedian A, Schiesser JV, Costa M, Sourris K, Ng E, Anderson D, Giudice A, Farlie P, Cheung M, Lamande SR, Penington AJ, Parish CL, Thomson LH, Rafii A, Elliott DA, Elef

(2016), Stem Cell Rep, 7(3)

Heavy menstrual bleeding and dysmenorrhea are improved by magentic resonance guided focused ultrasound surgery (MRgFUS) of adenomyosis

Jayaram R, Subbarayan K, Mithraprabhu S, Govindarajan M

(2016), Fertil Res Pract, 2

Retrospective review on isolated distal deep vein thrombosis (IDDVT) - a benign entity or not?

Ho P, Lim HY, Chua CC, Sleeman M, Tacey M, Donnan G, Nandurkar H

(2016), Thromb Res, 142

Molecular imaging of activated platelets allows the detection of pulmonary embolism with magnetic resonance imaging

Heidt T, Ehrismann S, HÖvener JB, Neudorfer I, Hilgendorf I, Reisert M, Hagemeyer CE, Zirlik A, ReinÖhl J, Bode C, Peter K, von Elverfeldt D, von Zur Muhlen C

(2016), Sci Rep, 6

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Guirguis AA, Slape CI, Failla LM, Saw J, Tremblay CS, Powell DR, Rossello F, Wei A, Strasser A, Curtis DJ

(2016), Cell Death Differ, 23(6)

Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukemia

Ghisi M, Kats L, Masson F, Li J, Kratina T, Vidacs E, Gilan O, Doyle MA, Newbold A, Bolden JE, Fairfax KA, de Graaf CA, Firth M, Zuber J, Dickins RA, Corcoran LM, Dawson MA, Belz GT, Johnstone RW

(2016), Cancer Cell, 30(1)

Platelet and erythrocyte sources of s1p are redundant for vascular development and homeostasis, but both rendered essential after plasma s1p depletion in anaphylactic shock

Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E

(2016), Circ Res, 119(8)

Humanizing the protease-activated receptor (par) expression profile in mouse platelets by knocking par1 into the par3 locus reveals par1 expression is not tolerated in mouse platelets

French SL, Paramitha AC, Moon MJ, Dickins RA, Hamilton JR

(2016), PLoS One, 11(10)

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

French SL, Arthur JF, Lee H, Nesbitt WS, Andrews RK, Gardiner EE, Hamilton JR

(2016), J Thromb Haemost, 14(8)

A-Disintegrin-And-Metalloproteinase (ADAM) 10 Activity on Resting and Activated Platelets

Facey A, Pinar I, Arthur JF, Qiao J, Jing J, Mado B, Carberry J, Andrews RK, Gardiner EE

(2016), Biochemistry, 55(8)

Targeting p38 or MK2 enhances the anti-leukemic activity of Smac-mimetics

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M,

(2016), Cancer Cell, 29(2)

Profiling clinical platelet and plasma use to inform blood supply and contingency planning: PUPPY, the prospective utilization of platelets and plasma study

Fedele PL, Polizzotto MN, Grigoriadis G, Waters N, Comande M, Borosak M, Portbury D, Wood EM

(2016), Transfusion, 56(10)

Multicentre randomised placebo-controlled trial of oral anticoagulation with apixaban in systemic sclerosis-related pulmonary arterial hypertension: the SPHInX study protocol

Calderone A, Stevens W, Prior D, Nandurkar H, Gabbay E, Proudman SM, Williams T, Celermajer D, Sahhar J, Wong PK, Thakkar V, Dwyer N, Wrobel J, Chin W, Liew D, Staples M, Buchbinder R, Nikpour M

(2016), BMJ Open, 6(12)

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J

(2016), Sci Transl Med, 8(339)

Isavuconazole as salvage therapy for mucormycosis

Graves R, Morrissey CO, Wei A, Coutsouvelis J, Ellis S, Pham A, Gooi J, Ananda-Rajah M

(2016), Med Mycol Case Rep, 11

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