Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Platelet hyperreactivity in diabetes: focus on GPVI signaling-are useful drugs already available?

Arthur JF, Jandeleit-Dahm K, Andrews RK

(2017), Diabetes, 66(1), 7-13

DOI: 10.2337/db16-1098

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood SE, Richart AL, Henstridge DC, Alt K, Kiriazis H, Zammit C, Carey AL, Kammoun HL, Delbridge LM, Reddy M, Chen YC, Du XJ, Hagemeyer CE, Febbraio MA, Siebel AL, Kingwell BA

(2017), Sci Transl Med, 9(411), eaam6084

DOI: 10.1126/scitranslmed.aam6084

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy CP, Yao Y, Kammoun H, Bonnard T, Hoefer T, Alt K, Tovar-Lopez F, Rosengarten G, Ramsland PA, van der Meer AD, van den Berg A, Murphy AJ, Hagemeyer CE, Peter K, Westein E

(2017), J Thromb Haemost, 15(5), 972-82

DOI: 10.1111/jth.13666

Pharmacokinetics and safety of carfilzomib in patients with relapsed multiple myeloma and end-stage renal disease (ESRD): an open-label, single-arm, phase I study

Quach H, White D, Spencer A, Ho PJ, Bhutani D, White M, Inamdar S, Morris C, Ou Y, Gyger M

(2017), Cancer Chemother Pharmacol, 79(6), 1067-76

DOI: 10.1007/s00280-017-3287-8

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

Stone RM, Mandrekar SJ, Sanford BL, Laumann K, Geyer S, Bloomfield CD, Thiede C, Prior TW, Dàhner K, Marcucci G, Lo-Coco F, Klisovic RB, Wei A, Sierra J, Sanz MA, Brandwein JM, de Witte T, Niederwieser D, Appelbaum FR, Medeiros BC, Tallman MS, Krauter J, Schlenk RF, Ganser A, Serve H, Ehninger G, Amadori S, Larson RA, Dàhner H

(2017), N Engl J Med, 377(5), 454-64

DOI: 10.1056/NEJMoa1614359

An individualised risk-adapted protocol of pre- and post transplant zoledronic acid reduces bone loss after allogeneic stem cell transplantation: results of a phase II prospective trial

Grigg A, Butcher B, Khodr B, Bajel A, Hertzberg M, Patil S, D'Souza AB, Ganly P, Ebeling P, Wong E

(2017), Bone Marrow Transplant, 52(9), 1288-93

DOI: 10.1038/bmt.2017.108

Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results

Hughes TP, Leber B, Cervantes F, Spector N, Pasquini R, Clementino NCD, Schwarer AP, Dorlhiac-Llacer PE, Mahon FX, Rea D, Guerci-Bresler A, Kamel-Reid S, Bendit I, Acharya S, Glynos T, Dalal D, Branford S, Lipton JH

(2017), Leukemia, 31(11), 2529-31

DOI: 10.1038/leu.2017.247

Platelet-targeted delivery of peripheral blood mononuclear cells to the ischemic heart restores cardiac function after ischemia-reperfusion injury

Ziegler M, Wang X, Lim B, Leitner E, Klingberg F, Ching V, Yao Y, Huang D, Gao XM, Kiriazis H, Du XJ, Haigh JJ, Bobik A, Hagemeyer CE, Ahrens I, Peter K

(2017), Theranostics, 7(13), 3192-206

DOI: 10.7150/thno.19698

Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury

Sashindranath M, Dwyer KM, Dezfouli S, Selan C, Crikis S, Lu B, Yuan Y, Hickey MJ, Peter K, Robson SC, Cowan PJ, Nandurkar HH

(2017), Purinergic Signal, 13(2), 259-65

DOI: 10.1007/s11302-017-9558-3

Novel thrombolytic drug based on thrombin cleavable microplasminogen coupled to a single-chain antibody specific for activated GPIIb/IIIa

Bonnard T, Tennant Z, Niego B, Kanojia R, Alt K, Jagdale S, Law LS, Rigby S, Medcalf RL, Peter K, Hagemeyer CE

(2017), J Am Heart Assoc, 6(2), e004535

DOI: 10.1161/JAHA.116.004535

An evidence-based approach to myeloma bone disease

Bingham N, Reale A, Spencer A

(2017), Curr Hematol Malig Rep, 12(2), 109-18

DOI: 10.1007/s11899-017-0370-5

The incidence and natural history of dasatinib complications in the treatment of chronic myeloid leukemia

Fox LC, Cummins KD, Costello B, Yeung D, Cleary R, Forsyth C, Tatarczuch M, Burbury K, Motorna O, Shortt J, Fleming S, McQuillan A, Schwarer A, Harrup R, Holmes A, Ratnasingam S, Chan KL, Hsu WH, Ashraf A, Putt F, Grigg A

(2017), Blood Adv, 1(13), 802-11

DOI: 10.1182/bloodadvances.2016003889

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, Josefsson EC, Kile BT, Jackson SP

(2017), Sci Transl Med, 9(409), eaam5861

DOI: 10.1126/scitranslmed.aam5861

Anti-fibrinolytics

Draxler DF, Medcalf RL, Gruen RL

(2016), In: Gonzalez E, Moore HB, Moore EE (eds), Trauma Induced Coagulopathy, Springer International Publishing

Modeling metazoan apoptotic pathways in yeast

Bloomer DT, Kitevska T, Brand IL, Jabbour AM, Nguyen H, Hawkins CJ

(2016), Methods Mol Biol, 1419

Sprouty

Masoumi Moghaddam S, Amini A

(2016), In: Encyclopedia of Signaling Molecules, 2nd edition, Springer, USA

Idarucizumab: an anticoagulant reversal agent for dabigatran

Brown AFT, Nandurkar H

(2016), Med Today, 17(11)

Editorial: the role of the plasminogen activating system in neurobiology

Medcalf RL, Lawrence DA

(2016), Front Cell Neurosci, 10

Epigenetics in the biology and treatment of multiple myeloma

Spencer A, Mithraprabhu S

(2016), Eur Oncol Haematol, 12(2)

Plasminogen and stroke: more is better

Medcalf RL

(2016), J Thromb Haemost, 14(9)