Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Jackson, Jacob Tony; Ng, Ashley; Shields, Benjamin James; Haupt, Sue Moody; Haupt, Ygal; McCormack, Matthew Paul

(2018), Blood Adv, 2(4), 347-360

DOI: 10.1182/bloodadvances.2017013243

Investigation of the variable In(Lu) phenotype caused by KLF1 variants

Fraser, Nicole S.; Knauth, Christine M.; Schoeman, Elizna M.; Moussa, Assia; Perkins, Andrew C.; Walsh, Terry; Millard, Glenda M.; Dean, Melinda M.; Hyland, Catherine A.; Flower, Robert L.

(2018), Transfusion, 58(10), 2414-2420

DOI: 10.1111/trf.14926

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

Conway, Ashlee; Brown, Fiona C; Hortle, Elinor J.; Burgio, Gaetan; Foote, Simon J; Morton, Craig James; Jane, Stephen M.; Curtis, David J.

(2018), Dis Model Mech, 11(5)

DOI: 10.1242/dmm.034678

Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging

Bonnard, Thomas; Jayapadman, Anand; Putri, Jasmine A.; Cui, Jiwei; Ju, Yi; Carmichael, Catherine; Angelovich, Thomas A.; Cody, Stephen H.; French, Shauna; Pascaud, Karline; Pearce, Hannah A.; Jagdale, Shweta; Caruso, Frank; Hagemeyer, Christoph E.

(2018), ACS Nano, 12(7), 6988-6996

DOI: 10.1021/acsnano.8b02588

Self-Assembled Metal–Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles

Besford, Quinn A.; Ju, Yi; Wang, Ting Yi; Yun, Gyeongwon; Cherepanov, Pavel V.; Hagemeyer, Christoph E.; Cavalieri, Francesca; Caruso, Frank

(2018), Small, 14(39), 1802342

DOI: 10.1002/smll.201802342

Mining the plasma cell transcriptome for novel cell surface proteins

Trezise, Stephanie; Karnowski, Alexander; Fedele, Pasquale L.; Mithraprabhu, Sridurga; Liao, Yang; D’costa, Kathy; Kueh, Andrew J.; Hardy, Matthew P.; Owczarek, Catherine M.; Herold, Marco J.; Spencer, Andrew; Shi, Wei; Willis, Simon N.; Nutt, Stephen L.; Corcoran, Lynn M.

(2018), Int J Mol Sci, 19(8), 2161

DOI: 10.3390/ijms19082161

Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis

N»bor, Danitza; Graber, Joel H.; Ciciotte, Steven L.; Robledo, Raymond F.; Papoin, Julien; Hartman, Emily; Gillinder, Kevin R.; Perkins, Andrew C.; Bieker, James J.; Blanc, Lionel; Peters, Luanne L.

(2018), Sci Rep, 8(1), 12793

DOI: 10.1038/s41598-018-30839-2

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

Conway, James R.W.; Warren, Sean C.; Herrmann, David; Murphy, Kendelle J.; Cazet, Aur»lie S.; Vennin, Claire; Shearer, Robert F.; Killen, Monica J.; Magenau, Astrid; M»l»nec, Pauline; Pinese, Mark; Nobis, Max; Zaratzian, Anaiis; Boulghourjian, Alice; Da Silva, Andrew M.; del Monte-Nieto, Gonzalo; Adam, Arne S.A.; Harvey, Richard P.; Haigh, Jody J.; Wang, Yingxiao; Croucher, David R.; Sansom, Owen J.; Pajic, Marina; Caldon, C. Elizabeth; Morton, Jennifer P.; Timpson, Paul

(2018), Cell Rep, 23(11), 3312-3326

DOI: 10.1016/j.celrep.2018.05.038

Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity

Tremblay, C»dric S.; Huang, Feng Fei; L»vesque, Georges; Carreau, Madeleine

(2018), BMC Res Notes, 11(1), 138

DOI: 10.1186/s13104-018-3243-7

Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis

Goldie, Stephen J.; Cottle, Denny L.; Tan, Fiona H.; Roslan, Suraya; Srivastava, Seema; Brady, Rhys; Partridge, Darren D.; Auden, Alana; Smyth, Ian M.; Jane, Stephen M.; Dworkin, Sebastian; Darido, Charbel

(2018), Cell Death Dis, 9(11), 1072

DOI: 10.1038/s41419-018-0901-6

Development of chondrocyte-seeded electrosprayed nanoparticles for repair of articular cartilage defects in rabbits

Yang, Shan Wei; Ku, Kai Chi; Chen, Shu Ying; Kuo, Shyh Ming; Chen, I. Fen; Wang, Ting Yi; Chang, Shwu Jen

(2018), J BIOMATER APPL, 32(6), 800-812

DOI: 10.1177/0885328217740729

A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury

Ziegler, M., Hohmann, J.D., Searle, A.K., Abraham, M.-K., Nandurkar, H.H., Wang, X., Peter, K.

(2018), Eur Heart J, 111-116

DOI: 10.1093/eurheartj/ehx218

CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages

Samudra, A.N., Dwyer, K.M., Selan, C., Freddi, S., Murray-Segal, L., Nikpour, M., Hickey, M.J., Peter, K., Robson, S.C., Sashindranath, M., Cowan, P.J., Nandurkar, H.H.

(2018), J Autoimmun, 131-138

DOI: 10.1016/j.jaut.2017.10.009

Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome

Kraakman, M.J., Kammoun, H.L., Dragoljevic, D., Al-Sharea, A., Lee, M.K.S., Flynn, M.C., Stolz, C.J., Guirguis, A.A., Lancaster, G.I., Chin-Dusting, J., Curtis, D.J., Murphy, A.J.

(2018), Haematologica, 597-606

DOI: 10.3324/haematol.2017.181958

The early in-vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation in healthy volunteers

Bain, C.R., Draxler, D.F., Taylor, R., Wallace, S., Gouldthorpe, O., Corcoran, T.B., Myles, P.S., L. Medcalf, R., Bozaoglu, K.

(2018), Anaesthesia, 955-966

DOI: 10.1111/anae.14306

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE

(2018), Cancer Discov, 8(12), 1582-1597

DOI: 10.1158/2159-8290.CD-18-0387

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

Teh TC, Nguyen NY, Moujalled DM, Segal D, Pomilio G, Rijal S, Jabbour A, Cummins K, Lackovic K, Blombery P, Thompson E, Ekert PG, Lessene G, Glaser SP, Huang DCS, Roberts AW, Guthridge MA, Wei AH

(2018), Leukemia, 32(2), 303-312

DOI: 10.1038/leu.2017.243

Dissecting causes for improved survival among patients with acute myeloid leukemia in two different eras receiving identical regimens in sequential randomized studies

Tiong IS, Reynolds J, Bradstock KF, Seymour JF, Wei AH; Australasian Leukaemia & Lymphoma Group

(2018), Blood Cancer J, 8(9), 84

DOI: 10.1038/s41408-018-0121-4

DCEP as a bridge to ongoing therapies for advanced relapsed and/or refractory multiple myeloma

Yuen HLA, Low MSY, Fedele P, Kalff A, Walker P, Bergin K, Coutsouvelis J, Grigoriadis G, Spencer A

(2018), Leuk Lymphoma, 59(12), 2842-2846

DOI: 10.1080/10428194.2018.1454595

Phase Ib study of the mTOR inhibitor everolimus with low dose cytarabine in elderly acute myeloid leukemia

Tiong IS, Tan P, McManus J, Cummings N, Sadawarte S, Catalano J, Hills R, Wei A

(2018), Leuk Lymphoma, 59(2), 493-496

DOI: 10.1080/10428194.2017.1334122

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