Research publications

Alfred Health research outcomes are published in a wide range of peer reviewed journals. 

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Time to repeal and replace response criteria for acute myeloid leukemia?

Bloomfield CD, Estey E, Pleyer L, Schuh AC, Stein EM, Tallman MS, Wei A

(2018), Blood Rev, 32(5), 416-425

DOI: 10.1016/j.blre.2018.03.006

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE

(2018), Cancer Discov, 8(12), 1582-1597

DOI: 10.1158/2159-8290.CD-18-0387

Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study

DiNardo CD, Pratz KW, Letai A, Jonas BA, Wei AH, Thirman M, Arellano M, Frattini MG, Kantarjian H, Popovic R, Chyla B, Xu T, Dunbar M, Agarwal SK, Humerickhouse R, Mabry M, Potluri J, Konopleva M, Pollyea DA

(2018), Lancet Oncol, 19(2), 216-228

DOI: 10.1016/S1470-2045(18)30010-X

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

Duarte D, Hawkins ED, Akinduro O, Ang H, De Filippo K, Kong IY, Haltalli M, Ruivo N, Straszkowski L, Vervoort SJ, McLean C, Weber TS, Khorshed R, Pirillo C, Wei A, Ramasamy SK, Kusumbe AP, Duffy K, Adams RH, Purton LE, Carlin LM, Lo Celso C

(2018), Cell Stem Cell, 22(1), 64-77

DOI: 10.1016/j.stem.2017.11.006

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

Merino D, Kelly GL, Lessene G, Wei AH, Roberts AW, Strasser A

(2018), Cancer Cell, 34(6), 879-891

DOI: 10.1016/j.ccell.2018.11.004

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

Teh TC, Nguyen NY, Moujalled DM, Segal D, Pomilio G, Rijal S, Jabbour A, Cummins K, Lackovic K, Blombery P, Thompson E, Ekert PG, Lessene G, Glaser SP, Huang DCS, Roberts AW, Guthridge MA, Wei AH

(2018), Leukemia, 32(2), 303-312

DOI: 10.1038/leu.2017.243

Dissecting causes for improved survival among patients with acute myeloid leukemia in two different eras receiving identical regimens in sequential randomized studies

Tiong IS, Reynolds J, Bradstock KF, Seymour JF, Wei AH; Australasian Leukaemia & Lymphoma Group

(2018), Blood Cancer J, 8(9), 84

DOI: 10.1038/s41408-018-0121-4

A case of multi-drug resistant ESBL-producing Shigella sonnei acute acalculous cholecystitis and gastroenteritis in a returned traveller

Williams E, Lew TE, Fuller A, Spelman DW, Jenney AW

(2018), J Travel Med, 25(1)

DOI: 10.1093/jtm/tay029

Mycobacterium abscessus complex: Natural history and treatment outcomes at a tertiary adult cystic fibrosis center

Tippett E, Ellis S, Wilson J, Kotsimbos T, Spelman D

(2018), Int J Mycobacteriol, 7(2), 109-116

DOI: 10.4103/ijmy.ijmy_55_18

Mathematical modelling of vancomycin-resistant enterococci transmission during passive surveillance and active surveillance with contact isolation highlights the need to identify and address the source of acquisition

Cheah ALY, Cheng AC, Spelman D, Nation RL, Kong DCM, McBryde ES

(2018), BMC Infect Dis, 18(1), 511

DOI: 10.1186/s12879-018-3388-y

Initial modelling and updates on cost effectiveness from the first 10 years of a spleen registry

Luu S, Jones P, Woolley I, Spelman D, Gold L

(2018), Aust N Z J Public Health, 42(5), 463-466

DOI: 10.1111/1753-6405.12832

A Registry for Patients With Asplenia/Hyposplenism Reduces the Risk of Infections With Encapsulated Organisms

Arnott A, Jones P, Franklin LJ, Spelman D, Leder K, Cheng AC

(2018), Clin Infect Dis, 67(4), 557-561

DOI: 10.1093/cid/ciy141

Management of neurosyphilis: time for a new approach?

Smibert OC, Jenney AWJ, Spelman DW

(2018), Intern Med J, 48(2), 204-206

DOI: 10.1111/imj.13703

Incidence and outcomes of catheter related thrombosis (CRT) in patients with acute leukemia using a platelet-adjusted low molecular weight heparin regimen

Htun KT, Ma MJY, Lee AYY

(2018), J Thromb Thrombolysis, 46(3), 386-392

DOI: 10.1007/s11239-018-1711-5

Failure to achieve early disease response is associated with inferior survival in patients with newly diagnosed multiple myeloma

Chee A, Low MS, Vilcassim S, Gregory GP, Gilbertson M, Ratnasingam S, Grigoriadis G, Fedele PL

(2018), Br J Haematol, 182(5), 739-741

DOI: 10.1111/bjh.14871

DCEP as a bridge to ongoing therapies for advanced relapsed and/or refractory multiple myeloma

Yuen HLA, Low MSY, Fedele P, Kalff A, Walker P, Bergin K, Coutsouvelis J, Grigoriadis G, Spencer A

(2018), Leuk Lymphoma, 59(12), 2842-2846

DOI: 10.1080/10428194.2018.1454595

Concentrating non-dilute urine before protein electrophoresis for the detection of monoclonal free light chains is unnecessary and wasteful

Haran H, Choy KW, Wijeratne N, Tudball R, Doery J, Grigoriadis G, Lu Z

(2018), Pathology, 50(5), 587-588

DOI: 10.1016/j.pathol.2018.02.004

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos

Fedele PL, Willis SN, Liao Y, Low MS, Rautela J, Segal DH, Gong JN, Huntington ND, Shi W, Huang DCS, Grigoriadis G, Tellier J, Nutt SL

(2018), Blood, 132(20), 2166-2178

DOI: 10.1182/blood-2018-05-850727

High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

Marquis M, Beaubois C, Lavall»e VP, Abrahamowicz M, Danieli C, Lemieux S, Ahmad I, Wei A, Ting SB, Fleming S, Schwarer A, Grimwade D, Grey W, Hills RK, Vyas P, Russell N, Sauvageau G, H»bert J

(2018), Blood Cancer J, 8(8), 68

DOI: 10.1038/s41408-018-0103-6

Australian multicentre study of current real-world prophylaxis practice in severe and moderate haemophilia A and B

Mason JA, Parikh S, Tran H, Rowell J, McRae S

(2018), Haemophilia, 24(2), 253-260

DOI: 10.1111/hae.13375

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