Medical Oncology research
The Medical Oncology Unit is a clinical service incorporating a research program that provides coordinated multidisciplinary care for patients with a wide range of malignancies.
The unit conducts clinical trials investigating new drug therapies such as targeted systemic treatments and chemotherapy in patients with malignancy. The main areas of research are in malignant melanoma and gastrointestinal malignancies.
In 2014 the unit continued to contribute to both national and international research projects, as well as phase 1, 2 and 3 clinical trials.
An evaluation of the outcomes of patients who achieved complete pathological responses to neo-adjuvant chemoradiotherapy for rectal cancer led us to change our practice to not routinely recommending post-operative chemotherapy to rectal cancer patients.Find out more
In 2014, our focus in melanoma research moved from advanced disease to treating earlier stage disease with the hope of finding effective systemic adjuvant treatments.Find out more
Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study
van den Bent MJ, Baumert B, Erridge SC, Vogelbaum MA, Nowak AK, Sanson M, Brandes AA, Clement PM, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Brachman DG, Taal W, Rudá R, Weller M, McBain C, Reijneveld J, Enting RH, Weber DC, Lesimple T, Clenton S, Gijtenbeek A, Pascoe S, Herrlinger U, Hau P, Dhermain F, van Heuvel I, Stupp R, Aldape K, Jenkins RB, Dubbink HJ, Dinjens WNM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, Wick W, Kros JM
(2017), Lancet, 390(10103), 1645-53
Efficacy of anti-PD-1 therapy in patients with melanoma brain metastases
Parakh S, Park JJ, Mendis S, Rai R, Xu W, Lo S, Drummond M, Rowe C, Wong A, McArthur G, Haydon A, Andrews MC, Cebon J, Guminski A, Kefford RF, Long GV, Menzies AM, Klein O, Carlino MS
(2017), Br J Cancer, 116(12), 1558-63
Tumour mutation status and sites of metastasis in patients with cutaneous melanoma
Adler NR, Wolfe R, Kelly JW, Haydon A, McArthur GA, McLean CA, Mar VJ
(2017), Br J Cancer, 117(7), 1026-35