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Our clinical trial portfolio is one of the largest in the country. We have more than 700 clinical trials open across 30 clinical units.

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665 clinical trials found
Clinical trials

BAF_FRontier-1

BAF_FRontier-1, A First-in-Human, Phase 1 Trial to Assess Safety, Tolerability, and Preliminary Efficacy of LY4152199, a B-cell Activation Factor Receptor [BAFF-R] T-Cell Engager Bispecific Antibody, in Adult Participants with Previously Treated B-cell Malignancies (NCT07101328)

LY4152199 is a human BAFF-R×CD3 bispecific antibody that engages BAFF-R on the surface of B-cells and CD3 on the surface of T-cells, with the goal of T-cell-mediated elimination of BAFF-R expressing malignant B-cells. Cohort A will assess the safety, tolerability, PK, and preliminary efficacy of escalating doses of LY4152199, administered via intravenous (IV) infusion, in participants with select relapsed/refractory B-cell malignancies. Cohort B will further assess the safety, tolerability, PK, and preliminary efficacy of LY4152199 in participants with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL).
Coming soon

BG-C0902-101

A Phase 1a/b Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BG-C0902, an Antibody-Drug Conjugate Targeting EGFR MET, Alone and in Combination with Other Therapeutic Agents in Patients with Advanced Solid Tumors (NCT07181681)

This study is a first-in-human (FIH), Phase 1a/1b study of BG-C0902, a fully humanized anti-epidermal growth factor receptor (EGFR) and anti-mesenchymal-epithelial transition (MET) antibody, conjugated via an enzymatically cleavable linker to a topoisomerase 1 (TOPO1) inhibitor payload. The study aims to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-C0902 in participants with advanced solid tumors. The study will be conducted in 2 phases: Phase 1a (dose escalation and safety expansion) and Phase 1b (dose expansion).
Currently recruiting