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Study participants will receive an intervention phone call from a Social Worker or Clinical Psychologist within 5-7 days of completing the screening tools [EuroQOL 5 Dmension 5 Level((EQ5D-5L), Primary Care PTSD screen for DSM-5 (PC-PTSD-5), Kessler 10 (K10) and Multidimensional Scale of Perceived Social Support )MSPSS)] in order to triage the participant for social work or psychology intervention and undertake initial goal setting. If scores indicate high distress, the research assistant or project lead will alert the Social worker (SW) and/or psychologist for priority call for risk assessment and treatment as indicated. The appropriate clinician and interventions to be delivered will be identified based on the results from the questionnaires. Social Work interventions include assessment and interventions related to housing/financial/legal issues, social supports, or emotional support. Clinical Psychology interventions include psychosocial support with focus on psychoeducation, psychological first aid, trauma informed emotional support and coping strategies. Both interventions will provide the patient with personalised resources, dependent on patient needs eg information regarding child support, family violence, Lifeline etc. The sessions will take place via phone call unless the patient has a strong desire for face to face meetings which could be facilitated. Depending upon the levels of distress and/or concerns raised by the participants in both response to the questionnaires and/ in the phone contact, psychology and/social work interventions will be provided as deemed clinically necessary. Community referrals will be facilitated as required, and duration and frequency of sessions will be considered in line with psychology and social work professional duty of care standards, hence the total duration is unknown but we anticipate that the follow up will be less than 2 months. Session completion records including length and number of treatments will be recorded.

CARISTA will test a new approach to predict risk for seasonal allergic asthma to identify treatable traits for preventing seasonal allergic asthma exacerbations to reduce the recurrent annual health threat of seasonal and thunderstorm asthma, address community and health care provider concerns and uncertainty regarding preventive treatment and management.

The purpose of this extension study is to collect long-term efficacy and safety data on barzolvolimab in adult participants with Chronic Spontaneous Urticaria (CSU) who completed the treatment and follow-up periods of the Phase 3 clinical trials. This study will also fulfill the Celldex commitment to provide post-trial access to participants who have completed the phase 3 studies, where applicable.

Peripheral arterial disease (PAD) is a condition which leads to narrowing and blockages in the large and medium-sized arteries which supply blood to your leg which typicalling requires angioplasty treatment. The ChampioNIR DES is a stent made of metal, coated with a mesh that can expand and which contains a drug called ridaforolimus. . Ridaforolimus stops cells from growing and replicating by attaching to a protein called mTOR, meaning that cells are less likely to build up around your stent and narrow your arteries.