Acute Myeloid Leukaemia Research Group
The Wei and Guthridge research groups focus on the mechanisms by which cancer cells co-opt and coerce intracellular signalling pathways to promote deregulated cell survival, proliferation and growth.
Through the molecular analysis of intracellular signalling pathways, the laboratories seek to identify new therapeutic targets in leukaemia. In 2015 Associate Professor Wei's group published research in Blood, demonstrating a previously unsuspected and clinically relevant role for INPP4B (inositol polyphosphate 4-phosphatase, type II B) as a mediator of chemoresistance associated with poor survival and outcome in AML. This apparent gain of function in mediating chemoresistance was found to be independent of the enzyme’s phosphoinositide phosphatase function (Rijal S et al., Blood 2015).