Anatomical Pathology research

The Department of Anatomical Pathology’s main research areas involve collaborative projects on breast cancer, liver cancer, prostate cancer, melanoma, muscle disease and neurodegenerative diseases.

Grants

Professor McLean is a co-investigator on the Victorian Cancer Agency Melbourne Melanoma Project Award (2014- 2017), of over $3 million, led by Professor Grant McArthur of Peter MacCallum Cancer Centre. The Victorian Melanoma Service is also a co-investigator on this project.

In collaboration with her Monash University partner Professor Christina Mitchell, Professor Catriona MacLean was awarded:

  • A five-year NHMRC Project Grant (2015-2019) of $916,231 entitled ‘Characterisation of autophagy deficiency in skeletal muscle homeostasis’ (CIA: Mitchell; CIC: McLean).
  • A 12-month Cancer Council Victoria Grant-in-Aid for 2015 of $100,000 entitled ‘Characterisation of a novel oncogenic pathway in breast cancer’ (CIA: Mitchell; CIB: McLean). Studies will be aimed at looking at both primary and secondary tumour growth.

Prizes

In 2014, trainee Dr Louise Jackett and Professor McLean were awarded first prize at the National Update in Pathology (a Royal College of Pathologists of Australia meeting) for their work on ‘Correlation of autopsy pathology with clinical diagnoses in life’. Appreciating the diagnoses that are missed provides an important contribution to improving clinical practice at Alfred Health.

Publications

Isolated IgG4-associated autoimmune hepatitis or the first manifestation of IgG4-related disease?

Cosentino, Carmela B.; Clayton-Chubb, Daniel Ian; McLean, Catriona; Roberts, Stuart; Kemp, William Wilson

(2023), HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 22(4), 415-417

DOI: 10.1016/j.hbpd.2022.10.001

A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease

Merrihew, G. E., Park, J., Plubell, D., Searle, B. C., Keene, C. D., Larson, E. B., Bateman, R., Perrin, R. J., Chhatwal, J. P., Farlow, M. R., McLean, C. A., Ghetti, B., Newell, K. L., Frosch, M. P., Montine, T. J., & MacCoss, M. J

(2023), Scientific data, 10(1), 206

DOI: 10.1038/s41597-023-02057-7

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients

Allen, N. C., Martin, A. J., Snaidr, V. A., Eggins, R., Chong, A. H., Fernandéz-Peñas, P., Gin, D., Sidhu, S., Paddon, V. L., Banney, L. A., Lim, A., Upjohn, E., Schaider, H., Ganhewa, A. D., Nguyen, J., McKenzie, C. A., Prakash, S., McLean, C., Lochhead, A., Ibbetson, J., … Damian, D. L

(2023), New England journal of medicine, 388(9), 804-812

DOI: 10.1056/NEJMoa2203086

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