Anatomical Pathology research
The Department of Anatomical Pathology’s main research areas involve collaborative projects on breast cancer, liver cancer, prostate cancer, melanoma, muscle disease and neurodegenerative diseases.
Professor McLean is a co-investigator on the Victorian Cancer Agency Melbourne Melanoma Project Award (2014- 2017), of over $3 million, led by Professor Grant McArthur of Peter MacCallum Cancer Centre. The Victorian Melanoma Service is also a co-investigator on this project.
In collaboration with her Monash University partner Professor Christina Mitchell, Professor Catriona MacLean was awarded:
- A five-year NHMRC Project Grant (2015-2019) of $916,231 entitled ‘Characterisation of autophagy deficiency in skeletal muscle homeostasis’ (CIA: Mitchell; CIC: McLean).
- A 12-month Cancer Council Victoria Grant-in-Aid for 2015 of $100,000 entitled ‘Characterisation of a novel oncogenic pathway in breast cancer’ (CIA: Mitchell; CIB: McLean). Studies will be aimed at looking at both primary and secondary tumour growth.
In 2014, trainee Dr Louise Jackett and Professor McLean were awarded first prize at the National Update in Pathology (a Royal College of Pathologists of Australia meeting) for their work on ‘Correlation of autopsy pathology with clinical diagnoses in life’. Appreciating the diagnoses that are missed provides an important contribution to improving clinical practice at Alfred Health.
In collaboration with The Alfred Neurosciences department, we published a paper in *Neurology, examining the neuropathology of a newly described syndrome CANVAS – cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome.Find out more
As part of a collaboration with Cancer Council, Victoria and International Colleagues at the University of Cambridge, we published work in Nature Communications and Human Molecular Genetics identifying new breast cancer risk gene loci and novel associations of regions of chromosome 2 with breast cancer.Find out more
Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
Grohmann M, Wiede F, Dodd GT, Gurzov EN, Ooi GJ, Butt T, Rasmiena AA, Kaur S, Gulati T, Goh PK, Treloar AE, Archer S, Brown WA, Muller M, Watt MJ, Ohara O, McLean CA, Tiganis T
(2018), Cell, 175(5), 1289-1306
Rhenium and technetium complexes of thioamide derivatives of pyridylhydrazine that bind to amyloid-β plaques
Fletcher SP, Noor A, Hickey JL, McLean CA, White JM, Donnelly PS
(2018), J Biol Inorg Chem, 23(7), 1139-1151
Clinicopathological characteristics and prognosis of patients with multiple primary melanomas
Adler NR, Kelly JW, Haydon A, McLean CA, Mar VJ
(2018), Br J Dermatol, 178(1), e44-45