Perioperative Medicine Platform Trial (NCT07186634)

Giving a lot of oxygen may decrease the risk of infections after surgery. On the other hand, it is also possible that giving a conservative amount of oxygen (instead of a large amount) might protect organ functions and improve other aspects of recovery after surgery. We are comparing three (3) different ways of giving oxygen. You have an equal chance of receiving one of the following three treatments during and after surgery: Liberal oxygen - at least 80% oxygen; Conservative oxygen - the smallest amount of oxygen needed to safely achieve normal oxygen levels in the blood (but more than the oxygen in room air); Standard oxygen - oxygen in a middle range between the liberal and conservative treatments.

Trial phase

Phase 4

Trial participation type

This trial has been designed for the Clinical Research of a Drug.

Principal investigator

Prof Paul Myles

Key inclusion data

INCLUSION: Adult patient (≥18 years of age at time of admission); Scheduled to undergo a surgical procedure with a skin incision, expected duration of at least 2 hours, and a planned overnight hospital stay of at least 1 night (including, but not limited to, cardiac surgery, orthopaedic surgery, obstetric, or gynaecological surgery). EXCLUSION: ASA physical status 5 (moribund, not expected to survive with or without an operation); Previous participation in PROMPT within the previous 30 days. PROMPT O2 DOMAIN SPECIFIC EXCLUSION CRITERIA: ASA 1 or 2; Previous bleomycin therapy; current suspected or proven infection; Undergoing surgery for a cardiac or intra-thoracic procedure; Receiving (acute or long-term) oxygen therapy prior to surgery; The treating clinician considers that there is a specific indication for a specific oxygen regimen during the perioperative period; Not planned to receive mechanical ventilation during surgery.