PACEmaker AUGMENTed AF ablation in participants with AF and sinus node disease – the PACE AUGMENT-AF Study (ACTRN12625000546459)

This study evaluates whether increased atrial pacing rate decreases AF recurrence and burden for patients with AF and sinus node dysfunction undergoing AF ablation.

Trial phase

Other

Trial participation type

This trial is for clinical research of something other than a drug or device.

Principal investigator

A/Prof Sandeep (Sunny) Prabhu

Key inclusion data

Inclusion criteria: Age greater than or equal to 65; Persistent AF, undergoing AF catheter ablation; Ongoing documented sinus node disease at least 1 month following catheter ablation defined as fatigue, presyncope, dyspnoea, reduced exercise tolerance, or other symptoms that can correlate with slower heart rate, and at least one of the following a) Mean sinus rhythm HR <60bpm on 24 Holter monitor b) Inability to meet >80% max predicted heart rate on exercise stress test; Medicare eligible, able to consent, and able to adhere to follow-up requirements. Exclusion: Contraindication to ablation or pacemaker implantation.