GuiDIng energy provision using indiREct CalorimeTry: a pilot feasibility randomised controlled trial in critically ill adults with obesity [DIRECT Trial] (NCT06053216)

Indirect calorimetry is the gold standard for measuring energy expenditure in critically ill patients, but its impact on outcomes versus predictive equations is unclear. This study assesses the feasibility of using repeated measurements to guide energy delivery in obese ICU patients, with a secondary goal of informing a larger trial.

Trial phase

Phase 2

Trial participation type

This trial has been designed for the Clinical Research of a Device.

Principal investigator

A/Prof Emma Ridley

Key inclusion data

Inclusion Criteria: Adult (? 18 years) patients; Body mass index ?30 kg/m2; Between day 3 and 6 of index ICU admission; Receiving invasive mechanical ventilation; Receiving enteral nutrition or parenteral nutrition. Exclusion Criteria: Receiving ECMO support; Major burns (?20% TBSA); Unable to perform indirect calorimetry within 24 hours of randomisation; Known pregnancy; Death is imminent; Treating clinician believes the study is not in the best interest of the patient.