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Endocrinology & Diabetes research
The Department of Endocrinology and Diabetes performs clinical research in the areas of diabetes and thyroid cancer as well as basic research in diabetic complications and regulation of growth factor activity.
Achievements
Professor Leon Bach (CIF) is part of a team led by Professor Mark Cooper (Baker Heart & Diabetes Institute), who were awarded $2.5 million for the JDRF/NHMRC Diabetes Complications Centre of Research Excellence for 2014-2019.
Dr Kathryn Hackman and James Lee completed PhDs on their respective topics of ‘Diabetes and lung transplantation’ and ‘Thyroid cancer and microRNA’.
Postgraduate students
- 2 PhD students
Current research
Mechanisms of diabetic complications
The high glucose levels characteristic of diabetes lead to complications such as kidney damage; however, the precise mechanisms by which this occurs is not understood.
Find out moreRegulation of growth factor activity
The insulin-like growth factor (IGF) system is perturbed in many diseases, including diabetic complications and cancer. Professor Bach’s laboratory studies IGF binding protein-6 (IGFBP-6) and, particularly, its role as an IGF-II inhibitor in cancer.
Find out moreNew technologies for diabetes treatment
In type 1 diabetes, damage to the pancreas prevents insulin secretion to regulate glucose levels in the blood.
Find out moreClinical trials in diabetes and thyroid care
Find out moreDiabetes burden
Find out morePartners
Publications
Diabetes reduces severity of aortic aneurysms depending on the presence of cell division autoantigen 1 (CDA1)
Li, J., Huynh, P., Dai, A., Wu, T., Tu, Y., Chow, B., Kiriazis, H., Du, X.-J., Bach, L.A., Wilkinson-Berka, J.L., Biros, E., Walker, P., Nataatmadja, M., West, M., Golledge, J., Allen, T.J., Cooper, M.E., Chai, Z.
(2018), Diabetes, 755-768
DOI: 10.2337/db17-0134
Effect of 6 months of hybrid closed-loop insulin delivery in adults with type 1 diabetes: A randomised controlled trial protocol
McAuley, S.A., De Bock, M.I., Sundararajan, V., Lee, M.H., Paldus, B., Ambler, G.R., Bach, L.A., Burt, M.G., Cameron, F.J., Clarke, P.M., Cohen, N.D., Colman, P.G., Davis, E.A., Fairchild, J.M., Hendrieckx, C., Holmes-Walker, D.J., Horsburgh, J.C., Jenkin
(2018), BMJ Open,
Effect of 6 months hybrid closed-loop insulin delivery in young people with type 1 diabetes: a randomised controlled trial protocol
de Bock M, McAuley SA, Abraham MB, Smith G, Nicholas J, Ambler GR, Cameron FJ, Fairchild JM, King BR, Geelhoed EA, Davis EA, O'Neal DN, Jones TW; Australian JDRF Closed-Loop Research Group
(2018), BMJ Open, 8(8), e020275