Endocrinology & Diabetes research
The Department of Endocrinology and Diabetes performs clinical research in the areas of diabetes and thyroid cancer as well as basic research in diabetic complications and regulation of growth factor activity.
Achievements
Professor Leon Bach (CIF) is part of a team led by Professor Mark Cooper (Baker Heart & Diabetes Institute), who were awarded $2.5 million for the JDRF/NHMRC Diabetes Complications Centre of Research Excellence for 2014-2019.
Dr Kathryn Hackman and James Lee completed PhDs on their respective topics of ‘Diabetes and lung transplantation’ and ‘Thyroid cancer and microRNA’.
Postgraduate students
- 2 PhD students
Current research
Mechanisms of diabetic complications
The high glucose levels characteristic of diabetes lead to complications such as kidney damage; however, the precise mechanisms by which this occurs is not understood.
Find out moreRegulation of growth factor activity
The insulin-like growth factor (IGF) system is perturbed in many diseases, including diabetic complications and cancer. Professor Bach’s laboratory studies IGF binding protein-6 (IGFBP-6) and, particularly, its role as an IGF-II inhibitor in cancer.
Find out moreNew technologies for diabetes treatment
In type 1 diabetes, damage to the pancreas prevents insulin secretion to regulate glucose levels in the blood.
Find out moreClinical trials in diabetes and thyroid care
Find out moreDiabetes burden
Find out morePartners
Publications
Overnight counter-regulatory hormone levels and next day glycemia in adults with type 1 diabetes during closed-loop insulin delivery versus sensor-augmented pump with low-glucose suspend
Graf A, Ward GM, Vogrin S, Sundararajan V, Sharifi A, De Bock MI, Jayawardene D, Loh MM, Horsburgh JC, Berthold CL, Paramalingam N, Bach LA, Colman PG, Davis EA, Grosman B, Jenkins AJ, Kumareswaran K, Kurtz N, Kyoong A, MacIsaac RJ, Roy A, Jones TW, O'Neal DN
(2017), Diabetes Technol Ther, 19(7), 438-9
"It is definitely a game changer": a qualitative study of experiences with in-home overnight closed-loop technology among adults with type 1 diabetes
Hendrieckx C, Poole LA, Sharifi A, Jayawardene D, Loh MM, Horsburgh JC, Bach LA, Colman PG, Kumareswaran K, Jenkins AJ, MacIsaac RJ, Ward GM, Grosman B, Roy A, O'Neal DN, Speight J
(2017), Diabetes Technol Ther, 19(7), 410-6
Human monocyte-derived dendritic cells exposed to hyperthermia show a distinct gene expression profile and selective upregulation of IGFBP6
Liso A, Castellani S, Massenzio F, Trotta R, Pucciarini A, Bigerna B, De Luca P, Zoppoli P, Castiglione F, Palumbo MC, Stracci F, Landriscina M, Specchia G, Bach LA, Conese M, Falini B
(2017), Oncotarget, 8(37), 60826-40