Anatomical Pathology research

The Department of Anatomical Pathology’s main research areas involve collaborative projects on breast cancer, liver cancer, prostate cancer, melanoma, muscle disease and neurodegenerative diseases.

Grants

Professor McLean is a co-investigator on the Victorian Cancer Agency Melbourne Melanoma Project Award (2014- 2017), of over $3 million, led by Professor Grant McArthur of Peter MacCallum Cancer Centre. The Victorian Melanoma Service is also a co-investigator on this project.

In collaboration with her Monash University partner Professor Christina Mitchell, Professor Catriona MacLean was awarded:

  • A five-year NHMRC Project Grant (2015-2019) of $916,231 entitled ‘Characterisation of autophagy deficiency in skeletal muscle homeostasis’ (CIA: Mitchell; CIC: McLean).
  • A 12-month Cancer Council Victoria Grant-in-Aid for 2015 of $100,000 entitled ‘Characterisation of a novel oncogenic pathway in breast cancer’ (CIA: Mitchell; CIB: McLean). Studies will be aimed at looking at both primary and secondary tumour growth.

Prizes

In 2014, trainee Dr Louise Jackett and Professor McLean were awarded first prize at the National Update in Pathology (a Royal College of Pathologists of Australia meeting) for their work on ‘Correlation of autopsy pathology with clinical diagnoses in life’. Appreciating the diagnoses that are missed provides an important contribution to improving clinical practice at Alfred Health.

Publications

Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity

Greatorex, S., Kaur, S., Xirouchaki, C. E., Goh, P. K., Wiede, F., Genders, A. J., Tran, M., Jia, Y., Raajendiran, A., Brown, W. A., McLean, C. A., Sadoshima, J., Watt, M. J., & Tiganis, T

(2023), Journal of clinical investigation, 134(3), e162533

DOI: 10.1172/JCI162533

Severe NAD(P)HX Dehydratase (NAXD) Neurometabolic Syndrome May Present in Adulthood after Mild Head Trauma

Van Bergen, N. J., Gunanayagam, K., Bournazos, A. M., Walvekar, A. S., Warmoes, M. O., Semcesen, L. N., Lunke, S., Bommireddipalli, S., Sikora, T., Patraskaki, M., Jones, D. L., Garza, D., Sebire, D., Gooley, S., McLean, C. A., Naidoo, P., Rajasekaran, M., Stroud, D. A., Linster, C. L., Wallis, M., … Christodoulou, J

(2023), International journal of molecular sciences, 24(4), 3582

DOI: 10.3390/ijms24043582

Acute leg pain and weakness in pregnancy: A new diagnosis of myotonic dystrophy

Heron, V. C., Thomas, A., Liu, B., Crosthwaite, A. A., Skrzypek, H., McLean, C. A., & Paizis, K

(2023), Obstetric medicine, 16(4), 253-5

DOI: 10.1177/1753495X221109738

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