Pathology research
Alfred Health Pathology Services incorporates Laboratory Haematology, Microbiology and Clinical Biochemistry (also known as Chemical Pathology) and Anatomical Pathology.
This year’s report focuses on Haematology. Anatomical Pathology, headed by Professor Catriona McLean, is also reported.
Laboratory Haematology is primarily a diagnostic and consultative service providing expertise in blood banking, laboratory-based general haematology, including morphology, coagulation and flow cytometry, immunology tests and diagnostic bone marrow biopsies. The unit incorporates a specialist multidisciplinary transfusion medicine team which audits transfusion safety and practice.
Research collaborations involve identifying and supplying material for various registries of the Transfusion Outcomes Research Collaborative; Australia and New Zealand Intensive Care Society’s TRANSFUSE trial; Clinical Haematology and Trauma Unit clinical trials; Australian Centre for Blood Diseases (ACBD), Australasian Leukaemia and Lymphoma Group and Nucleus Network.
Current research
- Development of highly sensitive flow cytometric techniques for detection of small volume minimal residual disease after potentially curative therapy, particularly in multiple myeloma and acute myeloid leukaemia (AML)
- Coagulopathy associated with mechanical circulatory assist devices and heart valve dysfunction (ACBD collaboration)
- PTP1B expression in myeloproliferative disorders as a marker of JAK-STAT pathway dysregulation
- Haematological and biochemical complications of dapsone therapy
- Predicting outcome in AML: molecular testing for founder mutations
- Blood product use in bone marrow transplant and cardiac surgery patients
- Pre-operative optimisation of haemoglobin in orthopaedic patients to limit need for transfusion
Achievements
- Dr Victoria Ling, Haematology RACP /RCPA Advanced Trainee, won the 2014 Victorian RACP Trainee Research Award for Excellence in Adult Medicine
- Dr Kay Htun, Haematology RACP /RCPA Advanced Trainee, won the 2014 Alfred Hospital prize for Best Advanced Physician Trainee Project
- Dr Mandy Davis, Haematologist and Transfusion Specialist, was awarded the WTMS (Whole Time Medical Specialist) grant of $56,000 for expansion of the BloodTrack program to improve safety of blood administration.
Acute Myeloid Leukaemia: predicting outcome
Find out moreInappropriate pre-operative testing
Find out moreSide effects of Ventricular Assist Devices (VADs)
Find out morePublications
Fleming S, Tsai XC, Morris R, Hou HA, Wei AH
(2023), Blood, 142(23), 2029-2033
Mu A, Klare WP, Baines SL, Ignatius Pang CN, Guérillot R, Harbison-Price N, Keller N, Wilksch J, Nhu NTK, Phan MD, Keller B, Nijagal B, Tull D, Dayalan S, Chua HHC, Skoneczny D, Koval J, Hachani A, Shah AD, Neha N, Jadhav S, Partridge SR, Cork AJ, Peters K, Bertolla O, Brouwer S, Hancock SJ, Álvarez-Fraga L, De Oliveira DMP, Forde B, Dale A, Mujchariyakul W, Walsh CJ, Monk I, Fitzgerald A, Lum M, Correa-Ospina C, Roy Chowdhury P, Parton RG, De Voss J, Beckett J, Monty F, McKinnon J, Song X, Stephen JR, Everest M, Bellgard MI, Tinning M, Leeming M, Hocking D, Jebeli L, Wang N, Ben Zakour N, Yasar SA, Vecchiarelli S, Russell T, Zaw T, Chen T, Teng D, Kassir Z, Lithgow T, Jenney A, Cole JN, Nizet V, Sorrell TC, Peleg AY, Paterson DL, Beatson SA, Wu J, Molloy MP, Syme AE, Goode RJA, Hunter AA, Bowland G, West NP, Wilkins MR, Djordjevic SP, Davies MR, Seemann T, Howden BP, Pascovici D, Tyagi S, Schittenhelm RB, De Souza DP, McConville MJ, Iredell JR, Cordwell SJ, Strugnell RA, Stinear TP, Schembri MA, Walker MJ
(2023), Nature communications, 14(1), 1530
Spelman D
(2023), 295-8