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The purpose of this study is to assess the clinical efficacy of selatogrel when self-administered upon occurrence of symptoms suggestive of an acute myocardial infarction (AMI) in participants at risk of having a recurrent AMI.

This is a phase 1b, open-label, multi-center trial of tarlatamab in combination with ZL-1310 with or without an anti-programmed death ligand 1 (PD-L1) in participants with small cell lung cancer (SCLC). This study is being done to learn more about how to treat SCLC, a disease in which cancer cells form in the tissues of the lung and may spread to other parts of the body such as the opposite lung, bone, brain, or bone marrow. The study will look at whether tarlatamab in combination with ZL-1310 (in Part 1 and Part 2) or tarlatamab, ZL-1310 and durvalumab (in Part 3) could be used to treat SCLC.

This is a multicenter, open-label Phase 1-1b study of [225Ac]Ac-A9-3408 in subjects with unresectable or metastatic melanoma. The goal of this trial is to see if this investigational drug is safe for adult patients with melanoma that has spread to other parts of the body or cannot be removed by surgery. It will also see if this investigational drug can shrink melanoma tumours in the body.

To evaluate the clinical outcomes of patients with bicuspid aortic stenosis treated with TAVI using the Sapien 3 valve based on the ABC sizing app