Stem Cell Biology Group
Our research focuses on the regulation of stem cells in haematopoietic and leukaemic cells through genetic and epigenetic studies.
We found that the genes Ap2a2 and Gpsm2 enhance haematopoietic stem cell self-renewal and now study whether their respective dysregulation affects leukaemia.
We constructed an Ap2a2 conditional knockout mouse model, which shows embryonic lethality when constitutively deleted. Haematopoietic specific deletion of Ap2a2 during development and adulthood is being assessed.