Platelets and Thrombosis Laboratory
Arterial thrombosis underlies heart attacks and strokes and is the most common cause of death in Australia.
Platelets are the blood cells that form arterial thrombosis and antiplatelet drugs are the major therapy for heart attack and stroke prevention. As a result, there is a major clinical need for improved drugs to block platelet function.
Our research aims to develop such drugs. Recent work has focused on our discoveries of two new antiplatelet drug targets with potential to prevent heart attack and stroke: one that involves intracellular signalling enzymes (PI3Ks; Mountford JK et al., Nat Commun 2015) and another that involves cell surface thrombin receptors (PARs; French SL et al., J Thromb Haemost 2016).