Leukaemia Signalling Pathways Group
The normal human immune system functions not only to remove infected cells but also to remove damaged or pre-cancerous cells.
Cancer cells are able to evade removal by acquiring mutations that result in increased survival, even in the presence of cues that would normally result in their removal.
Our laboratory is identifying pathways that can be targeted therapeutically to bypass the survival signal in cancer cells and promote their clearance. We have already shown that deleting kinases that are normally activated by lnterleukin-3 promotes clearance of AML.