Anatomical Pathology research

The Department of Anatomical Pathology’s main research areas involve collaborative projects on breast cancer, liver cancer, prostate cancer, melanoma, muscle disease and neurodegenerative diseases.

Grants

Professor McLean is a co-investigator on the Victorian Cancer Agency Melbourne Melanoma Project Award (2014- 2017), of over $3 million, led by Professor Grant McArthur of Peter MacCallum Cancer Centre. The Victorian Melanoma Service is also a co-investigator on this project.

In collaboration with her Monash University partner Professor Christina Mitchell, Professor Catriona MacLean was awarded:

  • A five-year NHMRC Project Grant (2015-2019) of $916,231 entitled ‘Characterisation of autophagy deficiency in skeletal muscle homeostasis’ (CIA: Mitchell; CIC: McLean).
  • A 12-month Cancer Council Victoria Grant-in-Aid for 2015 of $100,000 entitled ‘Characterisation of a novel oncogenic pathway in breast cancer’ (CIA: Mitchell; CIB: McLean). Studies will be aimed at looking at both primary and secondary tumour growth.

Prizes

In 2014, trainee Dr Louise Jackett and Professor McLean were awarded first prize at the National Update in Pathology (a Royal College of Pathologists of Australia meeting) for their work on ‘Correlation of autopsy pathology with clinical diagnoses in life’. Appreciating the diagnoses that are missed provides an important contribution to improving clinical practice at Alfred Health.

Publications

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients

Allen, N. C., Martin, A. J., Snaidr, V. A., Eggins, R., Chong, A. H., Fernandéz-Peñas, P., Gin, D., Sidhu, S., Paddon, V. L., Banney, L. A., Lim, A., Upjohn, E., Schaider, H., Ganhewa, A. D., Nguyen, J., McKenzie, C. A., Prakash, S., McLean, C., Lochhead, A., Ibbetson, J., … Damian, D. L

(2023), New England journal of medicine, 388(9), 804-812

DOI: 10.1056/NEJMoa2203086

Evaluation of dynamic dermoscopic features of melanoma and benign naevi by sequential digital dermoscopic imaging and total body photography in a high-risk Australian cohort

Nguyen J, Doolan BJ, Pan Y, Vestergaard T, Paul E, McLean C, Haskett M, Kelly J, Mar V, Chamberlain A

(2023), Australasian journal of dermatology, 64(1), 67-79

DOI: 10.1111/ajd.13975

Improving skin cancer management with ARTificial intelligence: A pre-post intervention trial of an artificial intelligence system used as a diagnostic aid for skin cancer management in a real-world specialist dermatology setting

Felmingham C, Pan Y, Kok Y, Kelly J, Gin D, Nguyen J, Goh M, Chamberlain A, Oakley A, Tucker S, Berry W, Darling M, Jobson D, Robinson A, de Menezes S, Wang C, Willems A, McLean C, Cranwell W, Adler N, Wada M, Foley P, Brack J, Cumming S, Byars G, Bowling A, Ge Z, Haskett M, Wolfe R, Mar V; SMARTI Study Group

(2023), JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 88(5), 1138-42

DOI: 10.1016/j.jaad.2022.10.038

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