This study will look to see if the immune checkpoint markers CTLA-4 and PD-1 can be found on white blood cells from the blood and lymph nodes of HIV+ participants taking ART. The study is trying to find out if CTLA-4 and PD-1 can be found on cells with latent HIV.
Eligible participants will undergo two sampling procedures within a 4 month period. Leukapheresis involves taking large amounts of blood out of one vein, removing the white blood cells via an automated cell separator and transfusing the rest of the blood back into another vein.
It takes 3-4 hours. A lymph node biopsy from a 2-7cm groin incision will be performed by an experienced surgeon in a day procedure using either a combination of local anaesthetic and sedation or a short general anaesthetic.
The procedure itself takes around 30 minutes.
Participants need to be on ART with a viral load < 50 copies/mL for 3 years.