Research publications | Alfred Health

Receiving four or fewer cycles of therapy predicts poor survival in newly diagnosed transplant-ineligible patients with myeloma who are treated with bortezomib-based induction

Boyle, Stephen; Wellard, Cameron; Moore, Elizabeth M.; Blacklock, Hilary; Harrison, Simon J.; Ho, Phoebe Joy; Hocking, Jay; McQuilten, Zoe K.; Quach, Hang; Spearing, Ruth; Wood, Erica M.; Spencer, Andrew; Mollee, Peter; ,

(2021), EUR J HAEMATOL, 107(4), 497-499

DOI: 10.1111/ejh.13677

TOP2A expression predicts responsiveness to carfilzomib in myeloma and informs novel combinatorial strategies for enhanced proteasome inhibitor cell killing

Reale, Antonia; Khong, Tiffany; Mithraprabhu, Sridurga; Savvidou, Ioanna; Hocking, Jay John; Bergin, Krystal Frances; Ramachandran, Malarmathy; Chen, Maoshan; Dammacco, Francesco; Ria, Roberto; Silvestris, Francesco; Vacca, Angelo; Reynolds, John; Spencer

(2021), LEUKEMIA LYMPHOMA, 62(2), 337-347

DOI: 10.1080/10428194.2020.1832659

Estimating the Productivity Impact of Acute Myeloid Leukemia in Australia Between 2020 and 2029, Using a Novel Work Utility Measure

Parker, Catriona; Liew, Danny; Ademi, Zanfina; Owen, Alice; Ayton, Darshini R; Wei, Andrew H.; Zomer, Ella

(2021), JCO ONCOL PRACT, 17(11), E1803-E1810

DOI: 10.1200/OP.20.00904

The Myeloma Landscape in Australia and New Zealand: The First 8 Years of the Myeloma and Related Diseases Registry (MRDR)

Bergin, Krystal; Wellard, Cameron; Moore, Elizabeth; McQuilten, Zoe; Blacklock, Hilary; Harrison, Simon J.; Ho, P. Joy; King, Tracy; Quach, Hang; Mollee, Peter; Walker, Patricia; Wood, Erica; Spencer, Andrew; ,

(2021), CL LYMPH MYELOM LEUK, 21(6), e510-e520

DOI: 10.1016/j.clml.2021.01.016

Real-world utilisation of ASCT in multiple myeloma (MM)

Bergin, Krystal; Wellard, Cameron; Augustson, Bradley; Cooke, Rachel; Blacklock, Hilary; Harrison, Simon J.; Ho, Joy; King, Tracy; Quach, Hang; Mollee, Peter; Walker, Patricia; Moore, Elizabeth; McQuilten, Zoe; Wood, Erica; Spencer, Andrew; ,

(2021), BONE MARROW TRANSPL, 56(10), 2533-2543

DOI: 10.1038/s41409-021-01308-8

Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine

Yeola, Avani; Subramanian, Shruthi; Oliver, Rema A.; Lucas, Christine A.; Thoms, Julie A.I.; Yan, Feng; Olivier, Jake; Chacon, Diego; Tursky, Melinda L.; Srivastava, Pallavi; Potas, Jason R.; Hung, Tzongtyng; Power, Carl; Hardy, Philip; Ma, David D.; Kili

(2021), SCI ADV, 7(3), eabd1929

DOI: 10.1126/sciadv.abd1929

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity

Wang, Jueqiong; Farkas, Carlos; Benyoucef, Aissa; Carmichael, Catherine; Haigh, Katharina; Wong, Nick; Huylebroeck, Danny; Stemmler, Marc P.; Brabletz, Simone; Brabletz, Thomas; Nefzger, Christian M.; Goossens, Steven; Berx, Geert; Polo, Jose M.; Haigh, J

(2021), PLOS BIOL, 19(9), e3001394

DOI: 10.1371/journal.pbio.3001394

MOMENTUM: momelotinib vs danazol in patients with myelofibrosis previously treated with JAKi who are symptomatic and anemic

Verstovsek, Srdan; Chen, Chih Cheng; Egyed, Miklós; Ellis, Martin; Fox, Laura; Goh, Yeow T.; Gupta, Vikas; Harrison, Claire; Kiladjian, Jean Jacques; Lazaroiu, Mihaela C.; Mead, Adam; McLornan, Donal; McMullin, Mary F.; Oh, Stephen T.; Perkins, Andrew; Pl

(2021), FUTURE ONCOL, 17(12), 1449-1458

DOI: 10.2217/fon-2020-1048

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

Van Thillo, Quentin; De Bie, Jolien; Seneviratne, Janith A.; Demeyer, Sofie; Omari, Sofia; Balachandran, Anushree; Zhai, Vicki; Tam, Wai L.; Sweron, Bram; Geerdens, Ellen; Gielen, Olga; Provost, Sarah; Segers, Heidi; Boeckx, Nancy; Marshall, Glenn M.; Che

(2021), NAT COMMUN, 12(1), 4164

DOI: 10.1038/s41467-021-24442-9

Shutting the gate: targeting endocytosis in acute leukemia

Tremblay, Cedric S.; Ting, Stephen B.; McCluskey, Adam; Robinson, Phillip J.; Curtis, David J.

(2021), EXP HEMATOL, 104, 17-31

DOI: 10.1016/j.exphem.2021.09.003

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Thijssen, Rachel; Diepstraten, Sarah T.; Moujalled, Donia; Chew, Edward; Flensburg, Christoffer; Shi, Melissa X.; Dengler, Michael A.; Litalien, Veronique; MacRaild, Sarah; Chen, Maoshan; Anstee, Natasha S.; Reljić, Boris; Gabriel, Sarah S.; Djajawi, Tirt

(2021), BLOOD, 137(20), 2721-2735

DOI: 10.1182/blood.2020010167

Transglutaminase-2, RNA-binding proteins and mitochondrial proteins selectively traffic to MDCK cell-derived microvesicles following H-Ras-induced epithelial–mesenchymal transition

Shafiq, Adnan; Suwakulsiri, Wittaya; Rai, Alin; Chen, Maoshan; Greening, David W.; Zhu, Hong Jian; Xu, Rong; Simpson, Richard J.

(2021), PROTEOMICS, 21(13-14), 2000221

DOI: 10.1002/pmic.202000221

Endothelial Dysfunction in the Brain

Sashindranath, Maithili; Nandurkar, Harshal H.

(2021), STROKE, 52(5), 1895-1904

DOI: 10.1161/STROKEAHA.120.032711

Translational Potential of RNA Derived From Extracellular Vesicles in Multiple Myeloma

Reale, Antonia; Khong, Tiffany; Mithraprabhu, Sridurga; Spencer, Andrew

(2021), FRONT ONCOL, 11, 718502

DOI: 10.3389/fonc.2021.718502

Human myeloma cell- and plasma-derived extracellular vesicles contribute to functional regulation of stromal cells

Reale, Antonia; Carmichael, Irena; Xu, Rong; Mithraprabhu, Sridurga; Khong, Tiffany; Chen, Maoshan; Fang, Haoyun; Savvidou, Ioanna; Ramachandran, Malarmathy; Bingham, Nicholas; Simpson, Richard J.; Greening, David W.; Spencer, Andrew

(2021), PROTEOMICS, 21(13-14), 2000119

DOI: 10.1002/pmic.202000119

Good Engraftment but Quality and Donor Concerns for Cryopreserved Hemopoietic Progenitor Cell Products Collected During the COVID-19 Pandemic

Purtill, Duncan; Hutchins, Cheryl; Kennedy, Glen; McClean, Andrea; Fraser, Chris; Shaw, Peter J.; Chiappini, Paul; Tao, Helen; Ma, David DF; Kabani, Karieshma; Bai, Lijun; Greenwood, Matthew; Bajel, Ashish; O'Flaherty, Elizabeth; Curtis, David J.; Purins,

(2021), Transplantation and Cellular Therapy, 27(12), 1022e1-1022e6

DOI: 10.1016/j.jtct.2021.09.012

Congenital Anemia Phenotypes Due to KLF1 Mutations

Perkins, Andrew C.; Bieker, James

(2021), J PEDIAT HEMATOL ONC, 43(1), e148-e149

DOI: 10.1097/MPH.0000000000001915

Early Endothelial Activation in a Mouse Model of Graft vs Host Disease Following Chemotherapy

Pereira, Melrine; Lee, Natasha Ting; Noonan, Jonathan; Willcox, Abbey E.H.; Calvello, Ilaria; Georgy, Smitha Rose; Selan, Carly; Chia, Joanne S.; Hauw, Wayne; Wang, Xiaowei; Peter, Karlheinz; Robson, Simon C.; Nandurkar, Harshal H.; Sashindranath, Maithil

(2021), FRONT IMMUNOL, 12, 708554

DOI: 10.3389/fimmu.2021.708554

Outcomes of non-myeloablative allogeneic stem cell transplant in older patients with acute myeloid leukaemia in first remission

Nguyen, Phillip C.; Manos, Kate; Fong, Chun Y.; Schwarer, Anthony P.; Tiong, Ing S.; Wei, Andrew H.; Kliman, David; Curtis, David J.

(2021), INTERN MED J, 51(11), 1954-1958

DOI: 10.1111/imj.15564

Low-coverage whole-genome sequencing of extracellular vesicle-associated DNA in patients with metastatic cancer

Nguyen, Bella; Wong, Nicholas C.; Semple, Tim; Clark, Michael; Wong, Stephen Q.; Leslie, Connull; Mirzai, Bob; Millward, Michael; Meehan, Katie; Lim, Annette M.

(2021), SCI REP-UK, 11(1), 4016

DOI: 10.1038/s41598-021-83436-1